By R. Charlier, P. Alexander and Z. M. Bacq (Auth.)

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Under these conditions Lindner and his co-workers (508) consider that, in a given animal, the electrocardiographic changes produced by pituitrin are extremely constant both qualitatively and quantitatively (the authors express it thus: " Wir konnten dabei die Feststellung machen dass beim gleichen Hund die EKG-Veränderungen sowohl in qualitativen als auch in quantitativen Hinsicht ausserordentlich konstant sind "), and that the method, used under the exact conditions which they define, can MEASUREMENT OF LUMEN CHANGES IN THE CORONARY VESSELS 41 be used for the pharmacological evaluation of dilators of the coronary arteries.

CD : right carotid artery. CG : left carotid artery. SCG: left subclavian artery. MEASUREMENT OF LUMEN CHANGES IN THE CORONARY VESSELS 31 varies with the rate of flow and is picked up by an induction mechanism connected to a recording system. g. of the Sanborn type). Variations in the mean rate of coronary flow are thus recorded and traced continuously; they can be measured volumetrically by means of a scale constructed at the time of the preliminary calibration of the rotameter. The advantages of this technique are multiple : (a) the cannulization by the internal route avoids interruption of the coronary circulation and the possible division of nerve fibres ; (b) the cannulized coronary artery receives normal blood under normal pressure ; (c) the right coronary artery receives its blood by the natural route from the aorta ; (d) there is no need for a pump, the heart performing its natural function.

With Hershgold and Steiner, however, Sapirstein (377) has come to modify his view: the method, which is based on the assumption of homogeneity of blood flow throughout all the ventricular musculature, would appear to be valuable as he found that, in the rat, the blood flow in the myocardium per gramme of muscle hardly differed in the two ventricles. Another more serious criticism has been formulated by Wiggers and his co-workers (269, 876). The nitrous oxide method is claimed to measure the coronary arterial flow and the oxygen consumption of the myocardium for the left ventricle, on the basis of Gregg's observations (331) that 90 to 95% of the venous flow in the coronary sinus comes from the left ventricle.

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