Examines the growth of prime scientists engaged on a variety of elements of handedness with the intention to examine the prevalence of handedness within the organic international. offers in-depth insurance of the foundation and improvement of morphological asymmetry taking place in so much different types of residing organisms.
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Additional info for Ciba Foundation Symposium 162 - Biological Asymmetry and Handedness
From experiments that Neil Mendelson and I have done, it is clear that they actually grow with a slight twist. We cannot demonstrate this for a single cell, but it can be seen in single filaments and measured in the multifilament structures that are formed under certain conditions. Whether the twist is right handed or left handed depends not only on the kind of mutant, but also on the ionic environment, what it feeds on, the temperature and so on. I can understand biologists wanting to relate this to molecular helices, but such ‘ a relation is unlikely because of the lack of regular structure in the cell wall at the molecular level.
Accessible Surface lo4 Area 1 Molecular Weight The correlation between the surface area that is accessible to solvent and the molecular weight of proteins. X, monomers; 0,dimers; 0 , tetramers; A , hexamers and octamers. From Janin et a1 (1988) with permission. FIG. 6. protein assemblies suggest that the asymmetrical nature of amino acids has little or no influence in their general design. The reason for this is the different nature of the interacting surfaces. Within proteins, the major interactions involve the close packing of the surfaces of individual a-helices and P-sheets; as I have discussed, the shapes of these surfaces are mainly the consequence of the asymmetrical nature of amino acids.
On the left are structures formed by straight strands; on the right are structures formed by twisted strands. (a) single strands; (b) two two-stranded sheets packed face-to-face and viewed along the strands; (c) the same structures viewed perpendicular to the interface between the sheets. The twist of the sheets rotates the main chain direction of the sheet nearest the viewer by an angle of -30" relative to the far sheet. C hot hia 42 FIG. 4. Schematic pictures of an ideal threestranded P-sheet and an a-helix in which the side chains on one face of each are shown as large open circles.