Chapter 1 Microbial pollution and Diarrhoeal ailments: advent and review (pages 1–13): R. L. Guerrant
Chapter 2 law of Water and Ion circulation in gut (pages 14–33): Don W. Powell, Helen M. Berschneider, Larry D. Lawson and Holger Martenst
Chapter three function of the Mucosal Barrier in Toxin/Microbial Attachment to the Gastrointestinal Tract (pages 34–56): W. Allan Walker
Chapter four pollution which turn on Adenylate Cyclase (pages 57–73): D. Michael Gill and Marilyn Woolkalis
Chapter five pollution which turn on Guanylate Cyclase: Heat?Stable Enterotoxins (pages 74–93): Mrinalini C. Rao
Chapter 6 STB Enterotoxin of Escherichia coli: Cyclic Nucleotide?Independent Secretion (pages 94–115): Cynthia S. Weikel and Richard L. Guerrant
Chapter 7 Mechanisms wherein Cyclic Nucleotides and different Intracellular Mediators control Secretion (pages 116–138): Hugo R. De Jonge and Suzanne M. Lohmannt
Chapter eight Secretory Hormones of Entamoeba histolytica (pages 139–154): Katherine McGowan, Victoria Guerina, Joan Wicks and Mark Donowitz
Chapter nine The Pharmacological amendment of Secretory Responses (pages 155–174): Richard J. Miller, David R. Brown, Eugene B. Chang and David D. Friel
Chapter 10 Salmonellosis: on reflection and Prospect (pages 177–192): J. Stephen, T. S. Wallis, W. G. Starkey, D. C. A sweet, M. P. Osborne and S. Haddon
Chapter eleven Shigella Toxin and the Pathogenesis of Shigellosis (pages 193–214): Gerald T. Keusch, Arthur Donohue?Rolfe and Mary Jacewicz
Chapter 12 Staphylococcus aureus Delta Toxin as an Entero Toxin (pages 215–229): Frank A. Kapral
Chapter thirteen Clostridial pollutants lively in the neighborhood within the Gastrointestinal Tract (pages 230–241): Tracy Wilkins, Howard Krivan, Bradley Stiles, Robert Carman and David Lyerly
Chapter 14 Vaccine improvement for the regulate of Cholera and similar Toxin?Induced Diarrhoeal ailments (pages 242–270): Jan Holmgren and Ann?Mari Svennerholm
Chapter 15 Chairman's Summing?Up (pages 271–274): Richard L. Guerrant

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Donowitz: Aren’t these crypt-like cells? Miller: I think so. Ruo: Does this cell line form tight junctions, show polarity and develop a 32 DISCUSSION resistance? In other words, can one do transepithelial ion transport studies with it? Miller: I don’t really know. Quaroni sent us four of these lines, so perhaps one of them will be useful for transport studies. Guerrunr: Of course, as we become more and more refined in our tools for examining a particular cell type, we run the risk of becoming less relevant in our studies to the natural, in vivo intestinal secretory system!

Walker: Unfortunately, not a great deal is known about the aetiology of necrotizing enterocolitis or other bacteriahoxin adherence mechanisms. We have preliminary evidence suggesting that when cholera toxin interacts with mucus from the immature or the mature animal, there is less adherence to mucus from immature animals, suggesting that there might be less interference with migration of the toxin through the mucus coat and therefore less inhibition of attachment to the microvillous surface in the immature animal (J.

The composition of the intestinal cell membrane changes as the epithelial cell migrates up the villus (Quaroni et a1 1980, Raul et a1 1977, DeBoth et a1 1975) and as the animal ages (Lojda 1974, Etzler & Branstrator 1979, Toofanian et a1 1974). Changes in membrane composition may determine whether bacteria or toxins bind to the cell. Bresson et a1 (1980) have studied isolated microvillous membranes from the intestine of newborn and adult rabbits. They have shown that the membrane protein/phospholipid ratio is dramatically decreased in newborn membranes compared to those of adults.

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