By Philip B. Mitchell, Dusan Hadzi-Pavlovic (auth.), Husseini K. Manji, Carlos A. Zarate Jr. (eds.)

Despite the devastating effect of bipolar illness at the lives of thousands world wide, many facets of its underlying etiology and pathophysiology stay unknown. This ebook, which has assembled a generally revered staff of preclinical and medical researchers, acts as a necessary and well timed source for either researchers and clinicians. This quantity stories the very newest organic, psychopharmacological, and healing literature that has ruled the sphere in recent times and accommodates state of the art translational examine. Early chapters overview the path and end result and genetics of this hugely heritable , together with chapters on epigenetics and medical endophenotypes. a number of chapters supply a remarkably thorough and targeted assessment of the neurobiology of the affliction, together with what's identified from genetics, molecular neurobiology, neuroimaging, and the improvement of animal versions. eventually, the publication covers remedy concepts for bipolar ailment, together with either conventional and novel therapeutics, in addition to non-pharmacological remedies. This ebook deals the original merits of mixing in-depth assurance of present clinical wisdom with functional scientific recommendation and a useful eye towards the way forward for the field.

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RNA-mediated gene silencing plays a pivotal role in maintaining chromosomal structure, genome defense, and gene regulation, and has recently been shown to play a significant role in disease progression (Almeida and Allshire 2005; Eckstein 2005; Guil and Esteller 2009; Mishima et al. 2009; Rosell et al. 2009). 3 Bipolar Disorder: The Epigenetic Perspective The epigenetic model of BPD and other complex diseases relies on three fundamental concepts formed from experimental observations: Understanding Bipolar Disorder: The Epigenetic Perspective 35 1.

Thus, cell types within a tissue and different tissue types have distinct “epigenotypes” to suit their needs of differential gene expression and provide phenotypic plasticity for a fixed genotype (Cheung et al. 2000a, 2005; Eckhardt et al. 2006). 2. Some epigenetic marks can display partial meiotic stability.

Psychol Med 34(5):777–785 Mitchell PB, Johnston AK, Corry J, Ball JR, Malhi GS (2009) Characteristics of bipolar disorder in an Australian specialist outpatient clinic: comparison across large datasets. Aust N Z J Psychiatry 43(2):109–117 Munk-Olsen T, Laursen TM, Mendelson T, Pedersen CB, Mors O, Mortensen PB (2009) Risks and predictors of readmission for a mental disorder during the postpartum period. Arch Gen Psychiatry 66(2):189–195 Oepen G, Baldessarini RJ, Salvatore P, Slater E (2004) On the periodicity of manic-depressive insanity, by Eliot Slater (1938): translated excerpts and commentary.

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