By Valentin Fuster MD PhD, Eric J. Topol MD, Elizabeth G. Nabel MD

Written by way of the world’s optimum experts, this quantity presents finished insurance of present techniques to the prevention, prognosis, and administration of atherothrombosis and its coronary and noncoronary issues. This version has been completely up-to-date, sharply all for medical details, and trimmed to 1 achievable volume.

Coverage starts off with a overview of danger elements and prevention, emphasizing lipid abnormalities, high blood pressure, smoking, diabetes, and weight problems. next sections study the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, continual sturdy angina, and noncoronary atherothrombosis. scientific shows, clinical administration, and the most recent interventional innovations are included.

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Labor force, accounting for 19% of disability allowances by the Social Security Administration. The five-year medical treatment cost for a myocardial infarction (for diagnostic and therapeutic services) in 1986 was $51,211 (6). Life expectancy in the United States is currently at its greatest level, chiefly as a consequence of the 49% ageadjusted decline in cardiovascular mortality during the last 25 years. This indicates the extent to which these leading causes of death are amenable to preventive and therapeutic measures.

It was no longer considered a casual observation at autopsies but was now regarded as a major cause of death” (15). Scientists sought to understand the pathophysiology of athero- GW_Fuster_CH001_0001-0014 9/23/04 12:42 PM Page 6 6 / CHAPTER 1 sclerosis, and patients and their doctors were eager for effective remedies for the many clinical problems that resulted from this process. This growing interest in atherosclerosis was reflected in the publication in 1933 of a 617-page book on the subject (16).

Observations on some of the most frequent and important diseases of the heart. Edinburgh: Bryce & Co, 1809. 30. Fye WB. T. Lauder Brunton and amyl nitrite: a Victorian vasodilator. Circulation 1986;74:222–229. 31. Fye WB. Nitroglycerin: a homeopathic remedy. Circulation 1986;73: 21–29. 32. Fye WB. The delayed diagnosis of acute myocardial infarction: it took half a century. Circulation 1985;72:262–271. 33. Fye WB, ed. Classic papers on coronary thrombosis and myocardial infarction. Birmingham, AL: Classics of Cardiology Library, 1991.

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