By Michel E. Safar, Edward D. Frohlich

This ebook provides the present considering foreign specialists concerning the underlying mechanisms of cardiovascular possibility in addition to the pathogenesis and pathophysiology of impaired huge arterial stiffness and diminished huge arterial distensibility. It additionally demonstrates the explanation for the current method of the administration and remedy of hypertensive ailments and atherosclerosis. The unique readership contains uncomplicated scientists in vascular body structure in addition to physicians and scientists in cardiovascular drugs, diabetes mellitus and renal illnesses.

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Additional resources for Atherosclerosis, large arteries and cardiovascular risk

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J Am Coll Cardiol 2005;46:1753–1760. Filipovsky J, Ticha M, Cifkova R, Lanska V, Stastna V, Roucka P: Large artery stiffness and pulse wave reflection: results of a population-based study. Blood Pressure 2005; 14:45–52. Woodman RJ, Kingwell BA, Beilin LJ, Hamilton SE, Dart AM, Watts GF: Assessment of central and peripheral arterial stiffness: studies indicating the need to use a combination of techniques. Am J Hypertens 2005;18:249–260. Lacy PS, O’Brien DG, Stanley AG, Dewar MM, Swales PP, Williams B: Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes.

James MA, Watt PA, Potter JF, Thurston H, Swales JD: Pulse pressure and resistance artery structure in the elderly. Hypertension 1995;26:301–306. Christensen KL: Reducing pulse pressure in hypertension may normalize small artery structure. Hypertension 1991;18:722–727. Ryan SM, Waack BJ, Weno BL, Heistad DD: Increases in pulse pressure impair acetylcholineinduced vascular relaxation. Am J Physiol 1995;268:H359–H363. Nigam A, Mitchell GF, Lambert J, Tardif JC: Relation between conduit vessel stiffness (assessed by tonometry) and endothelial function (assessed by flow-mediated dilatation) in patients with and without coronary heart disease.

Hypertension 2005; 46:221–226. Franklin SS, Pio JR, Wong ND, Larson MG, Leip EP, Vasan RS, Levy D: Predictors of new-onset diastolic and systolic hypertension: the Framingham Heart Study. Circulation 2005; 111: 1121– 1127. Izzo JL Jr: Arterial stiffness and the systolic hypertension syndrome. Curr Opin Cardiol 2004; 19:341–352. Mitchell GF, Pfeffer MA: Pulsatile hemodynamics in hypertension. Curr Opin Cardiol 1999; 14: 361–369. Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D: Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study.

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